Subcutaneous Panniculitis-like T Cell Lymphoma
Warning: This page is under construction and has not undergone final review.
Definition
- Predominantly subcutaneous lymphoma of cytotoxic T phenotype
Diagnostic Criteria
- Subcutaneous nodules
- Diffuse infiltrate
- Does not spare septa
- Dermis and epidermis rarely involved
- Vascular invasion may me seen
- Atypical cells vary from small, round to large and hyperchromatic
- Cytoplasm moderate, pale
- Atypical cells may form rings around necrotic fat cells
- Necrosis and karyorrhexis common
- Foamy histiocytes may be present in areas of fat destruction
- Cytotoxic T cell phenotype
- Most cases have alpha beta T cell receptors
- gamma delta variant
- More frequently also involve dermis and epidermis
- May be CD8 and CD4 negative and CD56+
- May be associated with pre-existing immunosuppression
- May represent 25% of total
- May instead be part of spectrum of mucosal/cutaneous gamma delta T cell lymphoma
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Initial posting : pending completion
