Hepatosplenic T Cell Lymphoma
Supplemental Studies
Immunohistology and Flow
- T lineage
- CD3
- Virtually 100%
- CD2
- Virtually 100%
- CD4
- Negative
- CD8
- <10%
- CD5
- Negative
- >90% express gamma/delta T cell receptors
- <10% express alpha/beta T cell receptors
- Cytotoxic granule protein antigens
- Granzyme B <5%
- Perforin negative
- CD56 >90%
- EBV about 10%
Genetic study
- T cell receptor gamma genes rearranged in most cases
- A subset may show instead beta gene rearrangement
- Isochromosome 7q has been identified in most cases studied
- Other abnormalities may also be seen
