Hepatosplenic T Cell Lymphoma
Differential Diagnosis
| Hepatosplenic T Cell Lymphoma |
Non-hepatosplenic T Cell Lymphoma |
| Involves liver, spleen, marrow |
Variable |
| Granzyme B usually negative |
Granzyme B often positive |
| Perforin usually negative |
Perforin often positive |
| EBV usually negative |
EBV positive in subset |
| Hepatosplenic T Cell Lymphoma |
T Large Granular Lymphocytic Leukemia |
| Involves liver, spleen, marrow |
Involves blood and marrow |
| Granzyme B usually negative |
Granzyme B positive |
| Perforin usually negative |
Perforin positive |
| Clinically aggressive |
Clinically indolent |
| Hepatosplenic T Cell Lymphoma |
Mucosa / Skin Associated T Cell Lymphoma |
| Predominantly involves liver and spleen |
Involves mucosa and/or skin but does not predominantly involve liver or spleen |
| Frequently involves marrow |
Usually does not involve marrow |
Immunophenotype overlaps and morphology of both is variable
