Hepatosplenic T Cell Lymphoma
Clinical
- Rare, <5% of peripheral T cell lymphomas
- Predominantly young adult males
- alpha beta T cell receptor subtype seen predominantly in females with wide age range
- Presents with hepatosplenomegaly
- Peripheral adenopathy rare
- Fever, anemia, thrombocytopenia and neutropenia usually present
- Leukocytosis may be present
- Cases have been reported following organ transplants
- Present later but with poorer prognosis than B cell PTLD
- Poor prognosis
