Angioimmunoblastic T Cell Lymphoma
Clinical
- Aggressive T cell lymphoma of middle-aged/older adults
- ~20% of peripheral T cell lymphomas
- Usually presents at advanced stage with constitutional symptoms, systemic lymphadenopathy+/- hepatosplenomegaly, and bone marrow involvement
- Occasionally involves extranodal sites, such as skin
- Constitutional symptoms and findings may include fever, pruritic skin rash, edema
- Polyclonal hypergammaglobulinemia
- Inflammatory disorders (arthritis, vasculitis, pleuritis)
- Autoimmune disorders (hemolytic anemia)
- Results in immunocompromised with susceptibility to infection
- Secondary lymphomas may develop
- usually diffuse large B cell lymphoma, often EBV+
- Prognosis poor
- Death frequently due to infection
