Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma
Supplemental Studies
Immunohistology
Synaptophysin | pos |
NB84 | pos |
Tyrosine hydroxylase | pos |
Neuron specifc enolase | pos |
CD45RB, B and T cell markers | neg |
Desmin, Myogenin, MyoD1 | neg |
Keratin, HMB45, S100, WT1, CD99 | neg |
Genetic Study
- MYCN oncogene amplification
- May be assessed by PCR or fluorescence in situ hybridization (FISH)
- In general, patients with MYCN amplified tumors have a worse prognosis