# Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma

## Differential Diagnosis

- Differential diagnosis is generally only a problem with the undifferentiated subtype presenting as a metastasis

Nblast | ALL | Ewing Sarc (PNET) | Rhabdo | MNTI | DSCT | Wilms Tumor | |
---|---|---|---|---|---|---|---|

Synapto | pos | neg | neg | neg | pos | neg | neg |

NB84 | pos | neg | neg | neg | neg | neg | neg |

CD45RB (LCA) | neg | pos | neg | neg | neg | neg | neg |

CD99 | neg | pos | pos | neg | rare | neg | neg |

Myogenin | neg | neg | neg | pos | rare | neg | neg |

MyoD1 | neg | neg | neg | pos | neg | neg | neg |

Keratin | neg | neg | rare | rare | pos | pos | neg |

Desmin | neg | neg | neg | pos | rare | pos | neg |

WT1(C) | neg | neg | neg | neg | neg | pos | pos |

S100 | neg | neg | rare | neg | rare | neg | neg |

HMB45 | neg | neg | neg | neg | pos | neg | neg |