Neuroblastoma, Ganglioneuroblastoma and Ganglioneuroma
Clinical
- Neuroblastoma is the most common extra-cranial solid tumor diagnosed in children age 5 years and younger
- Opsoclonus-Myoclonus-Ataxia (OMA) paraneoplastic syndrome affects 2-3% of patients with neuroblastoma
- These children are more likely to experience long term neurologic dysfunction and varying degrees of developmental delay
- Renal cell carcinomas have been reported to arise in the kidneys of patients with a history of neuroblastoma
- Most present about 10 years post diagnosis of neuroblastoma
- Most have been in treated patients but rare cases reported without radiation or chemotherapy
