Melanotic Neuroectodermal Tumor of Infancy

Supplemental Studies

Marker	Pigmented Epithelioid Cells	Neuroblastic Cells
HMB45	Pos	Neg
Keratin	Pos	Neg
Neuron Specific Enolase	Pos	Pos
Synaptophysin	Variable	Pos
CD56	Neg	Pos

Predominant reactivity from literature given above
- Even for these markers there is considerable variability in reports
Infrequent to rare positive cases are reported for the following:
- S100, CD99, Desmin, Actin, Myogenin, Chromogranin, GFAP, EMA, Neurofilaments
NB84 negative - both populations

There is no specific cytogenetic translocation
- A wide range of chromosomal abnormalities may be identified