Cellular Angiofibroma The first four entities are predominantly perineal in location and may be confused with cellular angiofibroma
Angiomyofibroblastoma Cellular Angiofibroma
Alternating hypercellular and hypocellular areas
Uniformly moderately cellular
Numerous small vessels
Hyalinized round vessels
Clusters of rounded, epithelioid cells, often around vessels
Bland spindle cells
Desmin positive most cases
Desmin about 10% of cases
Numerous small vessels
Large thick walled vessels
Actin frequently positive
Actin infrequently positive
Both may have fat in lesion, both may be CD34+.
Aggressive Angiomyxoma Cellular Angiofibroma
Usually large, deep lesion
Subcutaneous, mean size 6 cm
Hypocellular
Moderately cellular
Infiltrative margin
Circumscribed
Usually desmin positive
Desmin 10% positive
May infiltrate fat
May have fat integral to lesion
Both have prominent medium sized vessels, both may be CD34+.
Both are superficial and may be CD34 postive. Cellular angofibroma may occur in males.
Mammary-type Myofibroblastoma
Cellular Angiofibroma
Bundles of hyalinized collagen
Wispy collagen
Vessels inconspicuous
Vessels prominent
Desmin and CD34 generally positive
Desmin and CD34 variable
Both may contain adipose tissue
Cellular fibroma is virtually restricted to perineal, genital, inguinal regions, while the entities considered below may occur in a wide variety of sites.
Solitary Fibrous Tumor Cellular Angiofibroma
Alternating cellular and hypocellular areas
Generally uniformly cellular
Staghorn vessels prominent
Hyalinized round vessels prominent
Hyalinized collagen bundles frequent
Wispy collagen frequent
CD34+ nearly all cases
CD34+ 60% of cases
Spindle Cell Lipoma Cellular Angiofibroma
CD34+ nearly all cases
CD34+ 60% of cases
Essentially restricted to neck, upper back
Nearly all inguinal or perineal
Ropy collagen
Wispy collagen
Inconspicuous vessels
Prominent vessels
Fibroepithelial Stromal Polyp
Cellular Angiofibroma
Exophytic
Sessile
May have scattered atypical stromal cells
Uniform cells in most cases
