Soft Tissue Giant Cell Tumor of Low Malignant Potential
Definition
- Soft tissue tumor with a prominent population of osteoclast-like giant cells throughout, but lacking significant cytologic atypia
Alternate/historical Names
- Giant cell tumor of soft tissue
- Osteoclastoma of soft tissue
Diagnostic Criteria
- Multinodular infiltrative soft tissue tumor
- May be superficial or deep
- Three cell populations throughout
- Bland mononuclear cells
- Short spindled cells
- Osteoclast-like multinucleated giant cells
- More than mild atypia is not permitted
- Vesicular round to oval nuclei in all three cell populations
- Frequent mitotic figures, but none are atypical
- Necrosis is not permitted
- Frequent findings
- Vascular invasion
- Rim of reactive bone
- Angiectatic spaces
- Hemorrhage
- Hemosiderin laden macrophages
- Foamy macrophages
- Histologically resembles giant cell tumor of bone
- A bone primary must be ruled out radiographically
Richard L Kempson MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting: August 10, 2008
