Low Grade Fibromyxoid Sarcoma

Supplemental Studies

MUC4	100% strong diffuse positive (Doyle 2011)
Vimentin	positive
Smooth muscle actin	occasional focal weak positive
Desmin	occasional focal weak positive
Keratin	occasional focal weak positive
S100	occasional focal weak positive, may be positive in cells surrounding rosettes
CD34	occasional focal weak positive
EMA	occasional focal weak positive

Translocations involving fus t(7;16) seen in >90% and rarely t(11;16)
- These translocations are also identified in sclerosing epithelioid fibrosarcoma suggesting a relationship
  - Not present in other fibrous or myxoid neoplasms