Inflammatory Myofibroblastic Tumor
Clinical
- Primarily affects infants and children
- Age range 2 months to 46 years
- Virtually all under age 30
- Mean age 6-10 years
- Higher ages reported for cases involving the gastrointestinal and genitourinary tracts
- May cause systemic signs and symptoms
- Fever, weight loss, pain, malaise, night sweats
- Anemia, thrombocytosis, polyclonal hypergammaglobulinemia, elevated erythrocyte sedimentation rate
- May resolve following resection
- Most involve abdomen, mesentery
and lung
- Also reported in extremities, head and neck, brain
- Bladder involvement is controversial
- Some consider pseudosarcomatous myofibroblastic proliferations of the bladder to be a separate entity
- May be multifocal
- Size 1-20 cm
- Up to half may recur
- Recurrence rare if resection is complete
- Metastases occur in <5-10%
- Most often to lung, brain, liver, bone
