Pleomorphic Liposarcoma
Epithelioid Variant
Definition:
- Pleomorphic liposarcoma with prominent epithelioid features
Diagnostic Criteria for Epithelioid Variant
- Solid, cohesive sheets
- Lack extracellular matrix
- Separated by narrow vascular septa
- Epithelioid cells
- At least focally with cytoplasmic vaculoles
- Some cases with abundant clear to eosinophilic cytoplasm
- Nulcei generally round, uniform
- Mitotic figures frequent (21-101/10 hpf)
- Occasional pleomorphic nuclei
- Frequent necrosis
- Keratin positive in 5/11 cases
- Same clinical finding and anatomic distribution as other pleomorphic liposarcomas
- Poor prognosis (5/10 dead within one year)