Pleomorphic Liposarcoma
Differential Diagnosis
- Dedifferentiated liposarcoma
- Myxoid liposarcoma
- MFH and other pleomorphic non-lipogenic sarcoma
- Carcinoma (vs. epithelioid pleomorphic liposarcoma)
Pleomorphic Liposarcoma | Dedifferentiated Liposarcoma |
---|---|
Cellular pleomorphic sarcoma throughout | Atypical lipomatous areas present |
MDM2 and CDK4 negative | MDM2 95% and CDK4 92% |
Pleomorphic Liposarcoma is distinguished from MFH and other pleomorphic non-lipogenic sarcomas by the presence of lipoblasts in the former
Myxoid Liposarcoma does not demonstrate the degree of pleomorphism seen in Pleomorphic Liposarcoma
Epithelioid Variant Pleomorphic Liposarcoma | Carcinoma |
---|---|
Mucin negative large vacuoles | No large vacuoles unless mucin positive |
EMA negative | Most are EMA positive |
No glandular lumens | May have glandular lumens |