Lipoma
Variant: Myxolipoma / Angiomyxolipoma
Diagnostic Criteria
- Lipoma with prominent myxoid areas
- Must not contain lipoblasts
- If richly vascular, termed angiomyxolipoma
- Thin and thick walled vessels
- May be dilated
Supplemental Studies
- Spindle cells in myxoid areas
- Positive for CD34
- Negative for S100, smooth muscle actin, desmin
- Genetic studies have shown t(7;13) and t(8;12)
Differential Diagnosis
Myxoid Liposarcoma | Myxolipoma / Angiomyxolipoma |
---|---|
Prominent "chicken wire" vascular pattern | Lacks "chicken wire" vascular pattern |
May have lipoblasts | Lacks lipoblasts |
Very rare in subcutis or dermis | Usually in subcutis or dermis |
CD34 negative or scattered small cells | CD34 widely positive in myxoid areas |
t(12;16) or t(12;22) | t(7;13) or t(8;12) reported |
Myxolipoma | Spindle Cell Lipoma with Myxoid Stroma |
---|---|
Lacks prominent spindle cell component | Prominent spindle cell component |
May have prominent vascularity | Vascularity rarely prominent |
No dense collagen bundles | Dense ropy collagen bundles |
Location variable | Largely restricted to back, shoulders, posterior neck |
Clinical
- No clinical significance to this pattern
Bibliography
- Lee HW, Lee DK, Lee MW, Choi JH, Moon KC, Koh JK. Two cases of angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue. J Cutan Pathol. 2005 May;32(5):379-82.
- Tardio JC, Martin-Fragueiro LM. Angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue. Am J Dermatopathol. 2004 Jun;26(3):222-4.