Osteosclerotic Myeloma
Clinical
- Rare, apparently more prevalent in Japan
- Median age 50 years
- May be associated with HHV8 in setting of multicentric Castleman disease
- Signs and symptoms of POEMS syndrome
- Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes
- Occasional findings
- Edema/effusions/ascites, papilledema, clubbing
- Thrombocytosis, polycythemia
- Bone pain, fatigue
- Better prognosis than usual myeloma
- Median survival >14 years
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