Solitary Circumscribed Neuroma

Definition

Cutaneous nodular neuroma consisting of Schwann cells and numerous axons with a delicate perineurial capsule

Usually a solitary nodule
- Occasionally multinodular or plexiform
  - May have hyalinized vessels if plexiform
Circumscribed dermal or submucosal lesion
- Most only poorly and partially encapsulated (if at all)
- Helpful retraction artifact from the surrounding dermis
Comprised predominantly of spindled Schwann cells forming bundles/micro-fascicles
- Vague palisading may be present
  - Generally no significant, well formed palisading
  - Nuclear regimentation into Verocay bodies is occasionally present
- Mitotic activity and significant atypia are uncommon
Contain numerous axons throughout the nodule
Approximately 90% affect the face, lips or oral cavity

Jason Karamchandani MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342