Surgical Pathology Criteria

Pancreatic Neuroendocrine Microadenoma


Alternate/Historical Names

Diagnostic Criteria

Differential Diagnosis

Islet Cell Hyperplasia / Aggregation Pancreatic Neuroendocrine Microadenoma
Irregular, non-circumscribed Circumscribed
Usually multiple Usually solitary
Mixture of all four polypeptides Staining limited to 1 or 2 polypeptides
May be associated with chronic pancreatitis No association with chronic pancreatitis
Both are of no clinical significance

Acinar Cell Nodule of the Pancreas Pancreatic Neuroendocrine Microadenoma
Trypsin, chymotrypsin, lipase positive Chromogranin, synaptophysin positive
Usually basal nuclei Usually central nuclei
Usually apical granular eosinophilic cytoplasm Usually scant cytoplasm
Both are of no clinical significance


Classification / Lists

Pancreatic Endocrine Tumors


Author / Update

Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting/updates : 1/9/08, 5/18/08, 5/25/09, 1/1/12

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