Germ Cell Tumors of the Mediastinum / Thymus

Supplemental Studies

Immunohistology

• Germ cell tumor markers may be useful

  	Seminoma	Embryonal Carcinoma	Yolk Sac Tumor
  SALL4	100%	100%	100%
  OCT3/4	100%	100%	0%
  Glypican3	0%	0-8%	100%
  CD117	90%	0%	0%
  CD30	5%	90%	20%

  These markers are superior to placental alkaline phosphatase and alpha fetoprotein

• (Serum test for alpha fetoprotein is much more sensitive than immunohistochemistry)

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