Surgical Pathology Criteria

Papillary Adenoma

Differential Diagnosis

Papillary Renal Cell Carcinoma Papillary Adenoma
>1.5 cm diameter Papillary lesion ≤1.5 cm REQUIRED
May have any nuclear grade Nuclear grade 1 or 2 REQUIRED

Conventional Clear Cell Renal Cell Carcinoma Papillary Adenoma
No size cutoff for clear cell tumors Papillary lesion ≤1.5 cm, clear cells not permitted
May be high or low grade Must be no higher than grade 2
CK7, AMACR/racemase/P504S neg to focal CK7, AMACR/racemase/P504S pos

Two types of renal cell carcinoma are associated with end stage renal disease

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