Esophageal Submucosal Gland Duct Adenoma

Definition

Benign epithelial lesion exhibiting features of esophageal submucosal gland duct differentiation

Predominantly submucosal lesion with overlying unremarkable squamous mucosa
- Multiple communications to surface
  - May produce papillary areas
Circumscribed multilobulated lesion
- Not encapsulated
- No infiltrative pattern
Branching tubules and cystic lumens filled with papillae
All components predominantly lined by 2 layers of cells
- May occasionally be thicker
- Most cells cuboidal, occasionally columnar
- Luminal layer intensely eosinophilic
- No mucinous or gastric type cells
- May have focal squamous differentiation
Uniform, bland cytology
- Round to oval nuclei
- Small nucleoli
- Mitotic figures rare
Focal lymphoplasmacytic infiltrate with germinal centers
Focal acute inflammation in gland lumens and adjacent epithelium

Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342