Serrated Polyposis of the Colon and Rectum
Clinical
- Patients with syndrome are considered at risk for development of colorectal carcinoma
- Level of risk is unclear because of rarity of syndrome
- 15-55% incidence of cancer has been reported
- Referral bias may affect these numbers
- Increased screening of patients and first degree relatives is indicated
- Removal of lesions >1 cm is recommended
- Total or partial colectomy may be indicated if numerous
- Colorectal carcinomas arising in serrated polyposis are diverse in genotype (Rosty 2013)
- They are not restricted to microsatellite instability pathway
- Rare familial cases have been reported
- Pattern of heredity is not consistent
