Surgical Pathology Criteria

Tufting Enteropathy / Intestinal Epithelial Dysplasia


Alternate/Historical Name

Diagnostic Criteria

Differential Diagnosis

Tufting Enteropathy Microvillus Inclusion Disease
Surface epithelial tufts Apical cytoplasmic inclusions
Both may have scant inflammation with villous atrophy

Enteroendocrine Cell Dysgenesis Tufting Enteropathy
Normal villi Variable villus atrophy
No enterocyte disorder or tufting Surface epithelial crowding and tufting at villus tips
Markedly decreased or absent endocrine cells Endocrine cells present
Both present with neonatal diarrhea and lack significant inflammation


Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting / last update: 11/11/09, 1/17/15

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