Surgical Pathology Criteria

Ischemic Colitis

Differential Diagnosis

Pseudomembranous Colitis Ischemic Colitis
Diffuse Localized, may form a mass
No hyanization of lamina propria Hyalinized lamina propria
Occasional atrophic crypts Atrophic microcrypts common
Usually only superficial necrosis Necrosis frequently transmural
C difficile titer elevated C difficile titer negative
Associated with antibiotic therapy Not associated with antibiotic therapy


Incidental Chronic Colitis Ischemic Colitis (Chronic)
Crypt distortion and dropout Predominantly hyalinization and fibrosis
Prominent basal plasmacytosis Inflammation not prominent
Virtually restricted to cecum/right colon Most common in splenic flexure

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