Surgical Pathology Criteria

Chemical Iatrogenic Colitis

Differential Diagnosis

Chemical / Iatrogenic Colitis Antibiotic-associated Pseudomembranous Colitis
Diffuse necrosis and sloughing of superficial mucosa Frequently patchy involvement of 2-10 crypts with normal surrounding crypts
Mucosal microthrombi and hemorrhage Not associated with microthrombi or hemorrhage
History of endoscopy or introduction of foreign substance History of antibiotic therapy
Both may form a pseudomembrane

Chemical / Iatrogenic Colitis Acute Self-limited Colitis
Predominantly intramucosal hemorrhage with sloughing Predominantly acute inflammation in upper lamina propria and crypts

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