Celiac Disease
Supplemental Studies
Immunohistology
- CD3 or other pan-T cell marker is useful for identifying and counting T cells
Serology
- Quite sensitive and specific
- Especially useful for screening
- As 3% of celiac disease patients are IgA deficient, biopsy is necessary to rule out disease
| Test | Sensitivity | Specificity |
| IgG, IgA anti-gliadin antibody | 70% | 97% |
| IgA anti-endomysial antibody | 85-98% | 97-100% |
| IgA anti-tissue transglutaminase antibody | 95-98% | 94-95% |
