Surgical Pathology Criteria

Tubulolobular Carcinoma of the Breast

Differential Diagnosis

Tubular Carcinoma Tubulolobular Carcinoma
90% pure tubular pattern Mixed tubular and lobular patterns
Stellate infiltrating architecture Linear infiltrative pattern, frequently concentric
Both are typically E-cadherin positive

Tubulolobular Carcinoma Infiltrating Lobular Carcinoma
Contains a tubular component Uniform single file pattern
E-cadherin positive E-cadherin negative
Some consider tubulolobular carcinoma to be a variant of lobular carcinoma

Breast vs. other origin in carcinoma of unknown primary

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