Focal Pregnancy-like Change of the Breast
Definition
- Focal lactational change in a non-lactating, non-pregnant patient
Alternate/Historical Names
- Focal lactational change
- Pseudolactational change
- Focal lactating effect
Diagnostic Criteria
- The patient must be currently non-lactating and non-pregnant
- May be of any age
- Dilated acini lined by abundant pale vacuolated cytoplasm
- Lumenal cytoplasmic blebs
- Nuclei frequently contained in apical blebs
- Nuclei typically small, round, uniform
- Four cases reported with cytologic atypia, of unknown clinical significance (Shin)
- Increased nucleo/cytoplasmic ratio, pleomorphic nuclei, large nucleoli, mitoses identified
- Micropapillary architecture
- All four cases had associated cystic hypersecretory hyperplasia
- Four cases reported with cytologic atypia, of unknown clinical significance (Shin)
- Intraluminal calcifications described (Shin)
- Smooth contours, frequent eosinophilic border, uneven laminations
- “Precalcified” laminated proteinaceous deposits described
Richard L Kempson MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting: May 15, 2006
