Surgical Pathology Criteria–

Pseudoangiomatous Stromal Hyperplasia

Differential Diagnosis

Low Grade Angiosarcoma Pseudoangiomatous Stromal Hyperplasia
Endothelial lined spaces No endothelial lining of spaces
Red blood cells in some spaces No red blood cells in spaces
Infiltrates fat No infiltration of fat
Infiltrates lobules Merges with lobular stroma
Lining is CD31+ Lining is CD31 negative
Both contain anastomosing spaces containing CD34+ cells

 

Myofibroblastoma Pseudoangiomatous Stromal Hyperplasia
Uniformly cellular Even cellular lesions have classical paucicellular areas
No epithelial elements within lesion Typically surrounds ducts and lobules
At the cellular end of the spectrum, PASH shows many features of myofibroblastoma and the pseudovascular spaces may be obscured; the two are probably morphologic variants of the same lesion

 

Perilobular Hemangioma Pseudoangiomatous Stromal Hyperplasia
Endothelial lined spaces No true lining to spaces
CD31 positive CD31 negative
Red blood cells in some spaces No red blood cells in spaces
Both are usually incidental findings

 

Hemangioma Pseudoangiomatous Stromal Hyperplasia
Endothelial lined spaces No true lining to spaces
CD31 positive CD31 negative
Red blood cells in some spaces No red blood cells in spaces

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