Paget Disease of the Breast
Clinical
- Nearly all cases of mammary Paget disease are associated with underlying in situ or infiltrating breast carcinoma
- Demonstration of underlying lesion may require extensive examination of the breast
- Of females with known breast carcinoma, 1-4% may have Paget disease
- Higher incidence of 1-10% reported for males
- No clinical significance to the finding of Paget disease in a patient already known to have underlying carcinoma
- Typical presentation is as an eczematous eruption of the nipple
- May involve surrounding skin
- 10-28% of Paget disease cases have no abnormality of the nipple on clinical examination
