Surgical Pathology Criteria

Breast Carcinoma with Osteoclast-like Giant Cells

Differential Diagnosis

Metaplastic Carcinoma of the Breast with Mesenchymal Differentiation Carcinoma of the Breast with Osteoclast-like Giant Cells
Sarcomatous (malignant) stroma Only giant cells, no neoplastic stroma
May form osteoid (osteosarcoma) No osteoid
Other metaplastic carcinomas with non-mesenchymal differentation would not be confused with carcinomas with osteoclast-like giant cells

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