Surgical Pathology Criteria

Nipple Adenoma of the Breast

Differential Diagnosis

Radial Scar, Sclerosing Adenosis, Ductal Adenoma and Nipple Adenoma


Nipple Adenoma Infiltrating Syringomatous Adenoma of the Nipple
May have compressed ducts at edges but predominantly papillomatous Irregular, frequently compressed lumens throughout
Localized although not completely circumscribed Infiltrative
Stroma non-reactive Desmoplastic stroma
Squamous metaplasia may be present in papillomatosis resulting in confusion with syringomatous adenoma


Nipple Adenoma Intraductal Papilloma
Hyperplastic lesion with papillomatosis and/or adenosis Papillary fronds lacking florid hyperplasia


Nipple Adenoma Tubular Adenoma
Frequent prominent sclerosing stroma Scant stroma
Localized but not completely circumscribed Completely sharply circumscribed
Papillomatosis or adenomatosis with variable small glands Uniform glands

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