Surgical Pathology Criteria

Myoepithelioma of the Breast

Differential Diagnosis


Adenomyoepithelioma Myoepithelioma
Biphasic with myoepithelial and tubular components Purely myoepithelial, may surround normal ducts
Circumscribed May be stellate


Myoepithelial Carcinoma Myoepithelioma
Cytologically malignant Cytologically bland
Frequent mitotic figures Mitotically inactive
Necrosis may be present No necrosis


Myofibroblastoma Myoepithelioma
Circumscribed May be stellate
Keratini negative Keratin positive
CD34 positive CD34 not reported but expected to be negative


Metaplastic Carcinoma Myoepithelioma
Contains malignant epithelial component No epithelial component
Mesenchymal component, if present is usually cytologically malignant Bland spindle cell population

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