Inflammatory Carcinoma of the Breast
Supplemental Studies
Immunohistology
- Immunohistochemical staining of lymphatic endothelium may be helpful
- Positive markers CD31, CD34, D2-40
- CD34 also stains dendritic interstitial cells that frequently surround nests of carcinoma
- Close inspection on H&E is usually definitive
- Positive markers CD31, CD34, D2-40
- Keratin stain may be useful to highlight carcinoma in dermis
- Inflammatory carcinoma is typically
- E-cadherin positive
- Estrogen receptor negative
- MIB1 high
- MUC1 positive
- ERBB2 positive
