Urothelial (Transitional Cell) Carcinoma with Chordoid Features

Definition

• Subtype of urothelial carcinoma with abundant myxoid stroma

Alternate Name

• Urothelial carcinoma with abundant myxoid stroma (some cases)

Diagnostic Criteria

• Invasive urothelial carcinoma with abundant myxoid stroma
  • Faintly basophilic stroma
    • Alcian blue positive, mucicarmine faint
• Carcinoma cells arranged in cords
  • Reminiscent of chordoma or extraskeletal myxoid chondrosarcoma
  • Scant cytoplasm
  • May have microcystic pattern
• Stromal change may be focal or predominant

Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting/updates: 10/20/12

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