Lymphomatoid Granulomatosis Variant of Diffuse Large B Cell Lymphoma
Definition
- Angiocentric and angiodestructive lymphoproliferative disorder predominantly composed of large atypical EBV positive B cells
Alternate/Historical Names
- Polymorphic reticulosis
- Angiocentric immunoproliferative lesion
- Malignant angiitis
- Malignant granulomatosis
- Angiocentric lymphoma
Diagnostic Criteria
- Angiocentric and angiodestructive lymphoid infiltrate
- EBV positive B cells
- Must be predominiant population
- May form confluent sheets
- Prominent population of reactive T cells
- Extensive necrosis
- Virtually all cases involve lung
- Multiple pulmonary nodules
- Skin involved in nearly half of cases
- Dermal and subcutaneous nodules show similar features to lung
- May show nonspecific plaque like dermal infiltrate
- CNS and kidney also frequently involved
- If atypical cells are rare or only occasional, designate as Grade I or Low Grade Lymphomatoid Granulomatosis
Yasodha Natkunam MD PhD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 1, 2006
