Lymphomatoid Granulomatosis
Definition
- Angiocentric and angiodestructive lymphoproliferative disorder containing EBV positive B cells
Alternate/Historical Names
- Polymorphic reticulosis
- Angiocentric immunoproliferative lesion
- Malignant angiitis
- Malignant granulomatosis
- Angiocentric lymphoma
Diagnostic Criteria
- Angiocentric and angiodestructive lymphoid infiltrate
- EBV positive large atypical B cells
- Range from rare to predominiant
- Prominent population of small reactive T cells
- Necrosis
- Virtually all cases involve lung
- Multiple pulmonary nodules
- Skin involved in nearly half of cases
- Dermal and subcutaneous nodules show similar features to lung
- May show nonspecific plaque like dermal infiltrate
- CNS and kidney also frequently involved
- High grade lesions with preponderance of large atypical B cells are considered diffuse large B cell lymphoma, lymphomatoid granulomatosis variant
Yasodha Natkunam MD PhD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342
Original posting:: May 1, 2006
