Follicular Lymphoma
Signet Ring Variant of Follicular Lymphoma
- Nuclei displaced, frequently deformed by clear vacuoles or eosinophilic globules
- Most signet cells in follicles, occasionally interfollicular
- Clear vacuoles usually IgG positive
- EM shows microspherules and microvesicles
- Eosinophilic globules usually IgM positive
- EM shows membrane bound homogeneous electron dense material
- May mimic carcinoma
- May be seen rarely in other types of lymphoma
- No clinical significance
