Burkitt Lymphoma
Clinical
- Sporadic
- Median age 30 years
- 30-50% of childhood lymphomas
- <30% associated with EBV
- Most cases extranodal
- GI tract, ovary, breast, kidney, central nervous system
- Immunodeficiency associated
- Frequent HIV associated lymphoma
- More commonly involves nodes and marrow
- Endemic Burkitt lymphoma has a markedly different complex of clinical features
- Endemic zone includes equatorial Africa and Papua New Guinea
- Areas of high incidence correspond with areas of endemic malaria
- Most common pediatric neoplasm in this zone
- 95% of cases associated with EBV
- Peak incidence 4-7 years
- Most cases extranodal
- Half of cases involve facial bones
- GI tract, ovary, breast, kidney, central nervous system
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