Graft versus Host Disease (GVHD) of the Liver
Differential Diagnosis
Chronic viral hepatitis C
- Dense lymphoid aggregates
- Interface hepatitis
- Acidophil bodies
Drug induced damage
- Chemoirradiation effects last 3-4 weeks
- Other drugs can have hepatitis or cholestatic picture or granulomas
Primary biliary cirrhosis
- Can be difficult to distinguish from GVHD
- Features favoring PBC
-
Granulomas if present
- Florid bile duct lesions
Venocclusive disease
- Due to chemotherapy and radiation toxicity
- Usually presents 3 weeks after therapy
- Endothelial injury in sinusoids and venules
- May have fibrin thrombi
