Chronic Graft versus Host Disease (GVHD) of Gastrointestinal Tract
Differential Diagnosis
- Consider infection in the setting of acute or chronic inflammation, crypt abscesses or ulceration
- Use immunohistology to identify CMV or Herpes
- Enteritis may also be nonspecific
- Infection may coexist with GVHD
Chronic GI GVHD vs. Chemoradiation Effect
- Histologically, the two can be indistinguishable
- Submucosal fibrosis is uncommon in chemoradiation effect
- Chemoradiation effect can last 3-4 weeks while GVHD may occur later
