Surgical Pathology Criteria

Chronic Rejection of Transplanted Liver

Differential Diagnosis

Acute Rejection of Liver Chronic Rejection of Liver
1 week to 1 year post-transplant Presents > 6-12 months post-transplant
Bile duct lymphocytic infiltrate Bile duct loss in at least 50% of portal tracts
No cholestasis unless extensive bile duct damage Centrilobular cholestasis
No hepatocyte swelling Centrilobular hepatocyte swelling
No apoptotic bodies in lobules Scattered apoptotic bodies may be present

Diseases with a significant incidence of recurrence in transplants

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