Thymic Well Differentiated Neuroendocrine Carcinoma (Carcinoid and Atypical Carcinoid)
Supplemental Studies
Immunohistology and other studies
- Synaptophysin and/or chromogranin stains positive in most cases
- Argyrophil stain positive in nearly all cases
- Neuron specific enolase, PGP9.5 and CD56 are sensitive but not specific
- Somatostatin, ACTH, calcitonin and other secretory products may be identified
- S100 stains sustentacular cells in occasional cases
- Electronmicroscopy reveals neurosecretory granules
