Surgical Pathology Criteria

Metaplastic Thymoma

Definition

Alternate / Historical Names

Diagnostic Criteria

Supplemental Studies

  Keratin E Cadherin Vimentin CD20 CD5
Epithelioid Cells pos pos neg neg neg
Spindled Cells weak neg pos neg neg*
*One report of weak CD5 staining

Clinical

Differential Diagnosis

Metaplastic Thymoma Thymic Carcinoma with Sarcomatoid Differentiation
Cytologically bland Usually cytologically atypical
Mitotic figures rare Mitotic figures may be numerous
Metaplastic thymoma may have scattered bizarre nuclei but the general epithelial population is bland

Bibliography

Stanford Medicine Resources:

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