Surgical Pathology Criteria

Thymic Poorly Differentiated Neuroendocrine Carcinoma

Differential Diagnosis

Metastatic Large or Small Cell Neuroendocrine Carcinoma of Lung Primary Thymic Poorly Differentiated Neuroendocrine Carcinoma
History and imaging may reveal primary site History and imaging should reveal no other primary site
TTF1 positive in >90% of lung neuroendocrine carcinomas TTF1 negative (few tested)

 

Thymic Poorly Differentiated Neuroendocrine Carcinoma Thymic Carcinoid / Well Differentiated Neuroendocrine Carcinoma
Nearly always cytologically malignant Uniform cells with at most mild atypia
No clear cutoff is defined between these two

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