Lymphoma is positive for LCA, CD20 and other B lymphoid markers and negative for keratin
Grading / Staging
Well differentiated squamous carcinoma
Low grade mucoepidermoid carcinoma
High grade carcinomas
Large cell undifferentiated
Midline carcinoma with t(15;19)
(modified from Suster and Rosai)
The same TNM proposed for thymomas has been proposed for thymic carcinomas:
Invades through capsule into fat or normal thymus, but not through pleura or pericardium (may be adherent) or into adjacent organs
Invades through pleura or pericardium or into adjacent organs (great vessels, lung)
Pleural or pericardial implants
Metastasis only to anterior mediastinal nodes
Metastasis to other intrathoracic nodes
Metastasis to extrathoracic nodes
With distant metastases
From Tsuchiya et al. Pathol Int 1994; 44:506 and Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG eds. World Health Organization Classification of Tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart. IARC Press: Lyon 2015
An alternative system has been proposed by Moran
Encapsulated, no invasion of fat
Invasion of fat only
Invasion of innominate vein, mediastinal pleura or lung
Invasion of pericardium, aorta, superior vena cava or heart
Intrathoracic "drop" mets (discontinuous from primary) or nodes
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