Surgical Pathology Criteria

Extranodal NK/T Cell Lymphoma, Nasal Type

Supplemental Studies

Immunohistology and Flow

NK type
CD56 100%
EBV LMP Positive, less sensitive than in situ hybridization
CD3 Cytoplasmic positive, membrane negative
Cytotoxic granule proteins: granzyme B, TIA1, perforin Generally positive
CD43, CD45RO Generally positive
CD20, CD79a Rare positive cases reported
CD30 Occasionally positive
CD4, CD5, CD8 Negative

T cell type

CD56 Negative
CD3 Positive
CD5, CD8 May be positive
Cytotoxic granule proteins: granzyme B, TIA1, perforin Required for diagnosis
EBV Required for diagnosis

Genetic analysis

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