Surgical Pathology Criteria

Extranodal NK/T Cell Lymphoma, Nasal Type

Differential Diagnosis

Nonspecific Inflammatory Process vs. Extranodal NK/T Cell Lymphoma

Peripheral T Cell Lymphoma vs. Extranodal NK/T Cell Lymphoma, Nasal Type

Extranodal NK/T Cell Lymphoma Enteropathy Type T Cell Lymphoma
CD56 100% CD56 20%
EBV 100% in nasal sites but variable in other sites and outside endemic areas EBV variable, possibly by geography
No adjacent enteropathy Adjacent enteropathy 75%
Both may involve the GI tract and both express cytotoxic T markers

 

Lymphomatoid Granulomatosis vs. Extranodal NK/T Cell Lymphoma

Aggressive NK cell Leukemia

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