Extranodal NK/T Cell Lymphoma, Nasal Type
Clinical
- Most common in Asia and Latin America
- Sporadic cases in North America and Western Europe
- Most often presents with nasal obstruction and/or destruction of adjacent structures
- May extend into sinuses but does not primarily involve them
- Marrow and nodes involved only if disseminated
- Other sites
- Skin, soft tissue, GI tract, testis
- May have fever, malaise, weight loss
- Hemophagocytic syndrome may be present in disseminated cases
- Cases involving bone marrow overlap with aggressive NK cell leukemia, which may represent the leukemic counterpart of this lymphoma
